MGH
Job Description:
The Talkowski Laboratory in the Center for Genomic Medicine (CGM) at Massachusetts General Hospital (MGH) and the Broad Institute of MIT and Harvard is seeking a motivated, enthusiastic, experienced staff scientist to lead the CGM Genomics and Technology Core (GTC). The GTC is the primary genomics hub for the CGM, which encompasses 46 faculty engaged in all facets of human genetics and genomics research. The GTC is committed to the development and application of innovations in genomics methods for exome, genome, transcriptome, epigenome, and multiple other ‘omics technologies. The GTC provides all genomics research solutions, including molecular genomics and bioinformatics support, for CGM faculty and research programs within and outside the MGH, Harvard Medical School, and Broad Institute Communities. The candidate will lead the GTC and oversee the genomics programs within the Talkowski laboratory, which will include personnel management and training, project and program management, budget management, development and maintenance of standardized protocols and processes, as well as widespread interactions with faculty across our communities and institutions. Exceptional candidates will have extensive experience in genomics technology development and library production, in addition to outstanding organizational, interpersonal, and leadership skills.
Job Responsibilities:
- Perform basic analysis of genomics library metrics in tandem with the GTC Bioinformatics team.
- Coordinate with faculty, project leaders, and team members to ensure proper integration of data and workflow.
- Manage personnel including training, assignments and schedules to meet milestones and deadlines.
- Closely integrate and coordinate with the Broad Institute Genomics Platform.
- Prepare and present reports to PI and lab members.
- Manage submissions and create projections of data generation needs, timelines, and costs.
- Manage all equipment and consumable purchasing and maintenance.
- Train staff on new and existing techniques and protocols.
- Maintain laboratory notebook.
- Maintain project records.
- Supervise molecular genetics technicians and/or staff scientists to generate libraries and data using state-of-the-art genomics methods and technologies.
Job Requirements:
- Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab.
- Extensive expertise (5+ years) in genomics library generation (e.g., genome, exome, RNA-seq, amplicon-seq, capture-seq, ATAC-seq, ChIP-seq, scRNA-seq) and sequencing methods (e.g., Sanger, Illumina, PacBio, ONT).
- Ability to function with speed, precision, and an understanding of theory behind protocols and experiments.
- Extensive expertise (5+ years) in molecular biology techniques (e.g., PCR, qPCR, gel electrophoresis, DNA/RNA extraction quantification).
- Outstanding interpersonal skills and the ability to supervise and train scientific staff.
- Ability to work independently and as a team member.
- Excellent organizational and communication skills.
- Ability to troubleshoot library construction and sequencing results (e.g., experience with basic analysis including R, Unix environment, GATK pipeline).
Job Details:
Company: MGH
Vacancy Type: Full Time
Job Location: Springfield, MA, US
Application Deadline: N/A
